TY - DATA T1 - Supporting data for "Deep sequencing of human major histocompatibility complex region contributes to studies of complex disease" AU - Fusheng Zhou AU - Hongzhi Cao AU - Xianbo Zuo AU - Zhang, Tao AU - Wenjun Wang AU - Xiaomin Liu AU - Ricong Xu AU - Chen, Gang AU - Yuanwei Zhang AU - Xiaodong Zheng AU - Jin, Xin AU - Jinping Gao AU - Junpu Mei AU - Yujun Sheng AU - Qibin Li AU - Liang, Bo AU - Shen, Juan AU - Changbing Shen AU - Jiang, Hui AU - Caihong Zhu AU - Fan, Xing AU - Fengping Xu AU - Yue, Min AU - Xianyong Yin AU - Ye, Chen AU - Cuicui Zhang AU - Liu, Xiao AU - Yu, Liang AU - Jinghua Wu AU - Mengyun Chen AU - Xuehan Zhuang AU - Tang, Lili AU - Haojing Shao AU - Longmao Wu AU - Li, Jian AU - Xu, Yu AU - Yijie Zhang AU - Suli Zhao AU - Wang, Yu AU - Li, Ge AU - Hanshi Xu AU - Zeng, Lei AU - Jianan Wang AU - Mingzhou Bai AU - Yanling Chen AU - Chen, Wei AU - Kang, Tian AU - Yanyan Wu AU - Xu, Xun AU - Zhengwei Zhu AU - Cui, Yong AU - Zaixing Wang AU - Chunjun Yang AU - Peiguang Wang AU - Leihong Xiang AU - Chen, Xiang AU - Anping Zhang AU - Xinghua Gao AU - Furen Zhang AU - Jinhua Xu AU - Zheng, Min AU - Zheng, Jie AU - Jianzhong Zhang AU - Xueqing Yu AU - Yingrui Li AU - Yang, Sen AU - Jianjun Liu AU - Hammarstrom, Lennart AU - Liangdan Sun AU - Wang, Jun AU - Xuejun Zhang DO - 10.5524/100156 UR - http://gigadb.org/dataset/100156 AB - The human major histocompatibility complex (MHC) has been shown to be associated with numerous diseases. However, it remains a challenge to pinpoint causal variants of these associations due to the ex-treme complexity of the region. We thus sequenced the entire 5 Mb MHC region in 20,635 individuals of Han Chinese ethnicity (10,689 controls and 9,946 psoriasis patients) and constructed a Han-MHC da-tabase which included both variants and HLA gene typing results with high accuracy. We further identi-fied multiple independent novel susceptibility loci in HLA-C, HLA-B, HLA-DPB1, BTNL2 and an inter-genic variant, rs118178193 for psoriasis and confirmed the well-established susceptibility locus HLA-C*06:02. These discovered psoriasis-associated loci in MHC region were markedly different from those described in Caucasian population in a recent analysis and highlights the importance of generating population-specific MHC databases for studies of complex disease. We anticipate that our Han-MHC reference panel built by deep sequencing of a large number of samples will serve as a useful tool for investigating the role of the MHC region in a variety of diseases and thus advance our understanding of the pathogenesis of these disorders. KW - Genomic PY - 2015 PB - GigaScience Database LA - en ER -