10.14469/HPC/2663
Hooper, Tom
Tom
Hooper
https://orcid.org/0000-0001-7768-0938
Imperial College London
Palladium-Catalysed Carbon-Fluorine and Carbon-Hydrogen Bond Alumination of Fluoroarenes and Heteroarenes
Imperial College London
2017
Results
Imperial College London
Imperial College Research Computing Service
Hooper, Tom
Tom
Hooper
https://orcid.org/0000-0001-7768-0938
Imperial College London
White, Andrew
Andrew
White
https://orcid.org/0000-0001-6175-1607
Imperial College London
Crimmin, Mark
Mark
Crimmin
https://orcid.org/0000-0002-9339-9182
Imperial College London
2017
https://data.hpc.imperial.ac.uk/resolve/?ore=2663
10.14469/hpc/2664
10.14469/hpc/2665
10.14469/hpc/2666
10.14469/hpc/2667
10.14469/hpc/2668
10.14469/hpc/2669
10.14469/hpc/2670
10.14469/hpc/2671
10.14469/hpc/2672
10.14469/hpc/2673
10.14469/hpc/2674
Creative Commons: Public Domain Dedication 1.0
Through serendipitous discovery, a palladium bis(phosphine) complex was identified as a catalyst for the selective transformation of sp2CâF and sp2CâH bonds of fluoroarenes and heteroarenes to sp2CâAl bonds (19 examples, 1 mol% Pd loading). The carbonâfluorine bond functionalization reaction is highly selec-tive for the formation of organoaluminum products in preference to hydrodefluorination products (selectivity = 4.4:1 to 27:1). Evidence is presented for a two step mechanism in which hydrodefluorination is followed by sp2CâH alumination.