10.14469/HPC/6103
Bahou, Karim
Karim
Bahou
https://orcid.org/0000-0002-8302-5283
Imperial College London
Relay Cross Metathesis for the Iterative Construction of Terpenoids and Synthesis of a Diterpene-Benzoate Macrolide of Biogenetic Relevance to the Bromophycolides
Imperial College London
2019
Results
Imperial College London
Imperial College Research Computing Service
Bahou, Karim
Karim
Bahou
https://orcid.org/0000-0002-8302-5283
Imperial College London
Braddock, D. Christopher
D. Christopher
Braddock
https://orcid.org/0000-0002-4161-7256
Imperial College London
2019
https://data.hpc.imperial.ac.uk/resolve/?ore=6103
10.14469/hpc/5771
10.14469/hpc/5772
10.14469/hpc/5774
10.14469/hpc/5779
10.14469/hpc/5780
10.14469/hpc/5781
10.14469/hpc/5784
10.14469/hpc/5785
10.14469/hpc/5786
10.14469/hpc/5783
10.14469/hpc/5792
10.14469/hpc/5788
10.14469/hpc/5789
10.14469/hpc/5790
10.14469/hpc/5791
Creative Commons: Public Domain Dedication 1.0
We report a relay cross metathesis (ReXM) reaction for the ascent of the terpenoids in an iterative protocol. The protocol features the cross metathesis of a relay-actuated Δ6,7-functionalized C10-monoterpenoid alcohol with C10-monoterpenoid citral to form a C15-sesquiterpene. Subsequent functional group manipulation allows for the method to be repeated in an iterative fashion. The method is used for the synthesis of a diterpene-benzoate macrolide of biogenetic relevance to the bromophycolide family of natural products.