10.4123/SIDR.000003G.RP
Vivier, Eric
Eric
Vivier
Natural killer cells and innate immunity
Centre d'Immunologie de Marseille-Luminy (CIML), Université de la Méditerranée, INSERM U631, CNRS UMR6102, Parc Scientifique et Technologique de Luminy, Case 906, F13288 Marseille cedex 09, France
2010
Experiment report
Innate immunity
Transcriptomics
Mus musculus
Killer Cells, Natural
Spleen
Skin
Intestinal Mucosa
Transcription profiling
DNA microarray
INIST-CNRS
Zasadzinski, Alain
Alain
Zasadzinski
2010-07-12
2010
en
10.1038/ni.1681
10.1038/ni1582
10.1111/j.1600-065x.2007.00563.x
10.1016/j.coi.2007.04.004
10.4123/sidr.000003h.rp
10.4123/sidr.000003i.rp
99 ko
2 pages
PDF
Natural Killer (NK) cells are lymphocytes of the innate immune system that recognize and induce the lysis of a variety of target cells, including virally-infected cells, tumor cells, and allogenic cells without prior specific sensitization. In addition, NK cells elaborate a variety of regulatory cytokines including IFNg, TGFß1, TNFa, IL-1bß, IL-10, G-CSF, and GM-CSF and CC-chemokines, such as RANTES, MIP-1a and MIP-1bß which are involved in the elimination of intracellular pathogens in vivo, as well as in the generation of antigen-specific immune response. A feature of NK cell cytolytic activities and cytokine production is that their initiation is dependent upon the integrity of MHC class I expression on target cells. Indeed, NK cells express cell surface receptors such as KIR in humans, Ly49 in the mouse, and CD94/NKG2 heterodimers in both species, that can sense the alteration of MHC class I molecules at the surface of target cells.The main goal of our group is to contribute to the dissection of the functions of NK cells in vivo by elucidating the receptors that confer to NK cell the capacity to distinguish target from non-target cells. We believe that the results obtained in this aim will contribute to reveal novel mode of immune recognition and to precisely envision the potential indications of NK cell manipulation in novel immunotherapeutic strategies.
Cites: Ugolini S, Vivier E. Immunology: Natural killer cells remember. Nature. 2009 Jan 29;457(7229):544-5. PMID: 19177118
Cites: Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S. Functions of natural killer cells. Nat Immunol. 2008 May;9(5):503-10. Review. PMID: 18425107
Cites: Grégoire C, Chasson L, Luci C, Tomasello E, Geissmann F, Vivier E, Walzer T. The trafficking of natural killer cells. Immunol Rev. 2007 Dec;220:169-82. Review. PMID: 17979846
Cites: Walzer T, Jaeger S, Chaix J, Vivier E. Natural killer cells: from CD3(-)NKp46(+) to post-genomics meta-analyses. Curr Opin Immunol. 2007 Jun;19(3):365-72. Review. PMID: 17442558