10.5681/APB.2013.002
Zare Shahneh, Fatemeh
Fatemeh
Zare Shahneh
Mohammadian, Mozhdeh
Mozhdeh
Mohammadian
Babaloo, Zohreh
Zohreh
Babaloo
Baradaran, Behzad
Behzad
Baradaran
New Approaches in Immunotherapy of Behçet Disease
Tabriz University of Medical Sciences
2013
JournalArticle
610 Medical sciences; Medicine
2013-02-07
2013
en
text/html
Advanced Pharmaceutical Bulletin; eISSN 2251-7308
Behçet Disease (BD) is an autoimmune disorder with recurrent ocular, vascular, central nervous system, articular, mucocutaneous, and gastrointestinal manifestations with unclear etiology and pathogenesis. The further characterization of inflammatory features of Behçet’s disease may eventually lead to development of better treatment options. Clinical and laboratory observations suggested an important role of IL-17, IL-21 and neutrophil-mediated process in the pathogenesis of BD. New therapeutic modalities target specific and nonspecific suppression of the immune system. The various non-specific immunosuppressive drugs, used either alone or in combinations, frequently fail to control inflammation or maintain remissions. Due to encouraging clinical results (i.e. Antigenic specification, prolonged survival with acceptable levels of toxicity); antibody-based drugs could be effective for the clinical management of Behçet’s disease.
Advanced Pharmaceutical Bulletin; eISSN 2251-7308