10.5681/APB.2013.020
Mahani, Zoya Hojabri
Zoya Hojabri
Mahani
Ahangarzadeh Rezaee, Mohammad
Mohammad
Ahangarzadeh Rezaee
Nahaei, Mohammad Reza
Mohammad Reza
Nahaei
Soroush, Mohammad Hossein
Mohammad Hossein
Soroush
Davodi, Mostafa
Mostafa
Davodi
Satarzadeh Tabrizi, Mahboube
Mahboube
Satarzadeh Tabrizi
Ghazi, Mona
Mona
Ghazi
Bigverdi, Reza
Reza
Bigverdi
Pajand, Omid
Omid
Pajand
Aghazadeh, Mohammad
Mohammad
Aghazadeh
Comparison of in Vitro Activity of Doripenem versus Old Carbapenems against Pseudomonas Aeruginosa Clinical Isolates from both CF and Burn Patients
Tabriz University of Medical Sciences
2013
JournalArticle
610 Medical sciences; Medicine
2013-02-07
2013
en
text/html
Advanced Pharmaceutical Bulletin; eISSN 2251-7308
Purpose: The antimicrobial activity of doripenem in comparison of imipenem, meropenem and ertapenem among Pseudomonas aeruginosa isolated from burn and Cystic Fibrosis (CF) patients were determined. Methods: Metallo-β-lactamase (MBL) genes in imipenem non susceptible P. aeruginosa isolates were detected using PCR method. The in vitro susceptibilities of doripenem, imipenem, meropenem and ertapenem were determined by Etests. MIC50 and MIC90 for corresponding antibiotics were determined individually in burn and CF isolates. Results: Among isolates which were resistant to imipenem, 16 isolates were positive for the bla IMP gene. All isolates had no bla VIM gene. All MBL producing isolates were excluded. MIC50/MIC90 of doripenem in CF and burn isolates were 0.75/>32 and >32/>32 mg/L respectively. The corresponding values for imipenem in CF and burn isolates were 2/>32 and >32/>32 mg/L, respectively. Conclusion: The susceptibility rate of doripenem is higher than that of imipenem and meropenem among P.aeruginosa isolated from CF patients, whereas, there is no difference between the efficiency of doripenem and old carbapenems in non MBL producing P.aeruginosa isolates in burn patients.
Advanced Pharmaceutical Bulletin; eISSN 2251-7308