10.5681/JCVTR.2013.014
Sanaie, Sarvin
Sarvin
Sanaie
Ebrahimi-Mameghani, Mehrangiz
Mehrangiz
Ebrahimi-Mameghani
Mahmoodpoor, Ata
Ata
Mahmoodpoor
Shadvar, Kamran
Kamran
Shadvar
EJ Golzari, Samad
Samad
EJ Golzari
Effect of a Probiotic Preparation (VSL#3) on CardiovascularRisk Parameters in Critically-Ill Patients
Tabriz University of Medical Sciences
2013
JournalArticle
610 Medical sciences; Medicine
2013-06-22
2013
en
text/html
Journal of Cardiovascular and Thoracic Research
Introduction: Cardiovascular disease (CVD) counts for a major portion of morbidity and mortality globally mostly accompanied by lipid abnormalities. Being at increased risk of cardiac injury, critically ill patients suffer from various lipid disorders. Lipid homeostasis has been efficiently restored by the introduction of probiotics. The aim of this trial was to determine the effect of probiotics on inflammation, antioxidant capacity and lipid peroxidation in critically ill patients.;
Methods: Forty patients admitted to the intensive care unit were randomized to receive placebo or probiotic for 7 days. Serum levels of triglyceride (TG), total cholesterol, HDL-C, LDL-C and high- sensitivity C-reactive protein (hs-CRP) were measured before initiation of the study and on the 7th day.;
Results: There was a significant difference between two groups regarding the levels of TG, HDL and hs-CRP at the end of the study (P= 0.043, <0.001 and 0.003, respectively); however, there was not a significant difference in total cholesterol and LDL-C levels.;
Conclusion: Administration of probiotics in critically ill patients reduced the levels of TG and hs-CRP and increased HDL-C levels. However, no significant change was detected in levels of total cholesterol or LDL-C.
Journal of Cardiovascular and Thoracic Research